General Information

  • ID:  hor006053
  • Uniprot ID:  Q7M3T3
  • Protein name:  Vespakinin-M
  • Gene name:  NA
  • Organism:  Vespa mandarinia (Asian giant hornet)
  • Family:  Bradykinin-related peptide family
  • Source:  animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Vespa (genus), Vespinae (subfamily), Vespidae (family), Vespoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta (class), Hexapoda (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  GO:0090729 toxin activity
  • GO BP:  GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  GRPPGFSPFRID
  • Length:  12
  • Propeptide:  GRPPGFSPFRID
  • Signal peptide:  NA
  • Modification:  T4 4-hydroxyproline
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Bradykinins are a potent but short-lived agent of arteriolar dilation and increased capillary permeability (By similarity). May target bradykinin receptors (BDKRB). May cause hypotension.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006053_AF2.pdbhor006053_ESM.pdb

Physical Information

Mass: 154189 Formula: C62H92N18O16
Absent amino acids: ACEHKLMNQTVWY Common amino acids: P
pI: 10.4 Basic residues: 2
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -73.33 Boman Index: -2920
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.5
Instability Index: 9393.33 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  1017116
  • Title:  Vespakinin-M, a novel bradykinin analogue containing hydroxyproline, in the venom of Vespa mandarinia Smith.